منابع مشابه
Diagnosis of Parkinson’s Disease in Human Using Voice Signals
A full investigation into the features extracted from voice signals of people with and without Parkinson’s disease was performed. A total of 31 people with and without the disease participated in the data collection phase. Their voice signals were recorded and processed. The relevant features were then extracted. A variety of feature selection methods have been utilized resulting in a good perf...
متن کاملAberrant metal binding by prion protein in human prion disease.
Human prion diseases are characterized by the conversion of the normal prion protein (PrP(C)) into a pathogenic isomer (PrP(Sc)). Distinct PrP(Sc) conformers are associated with different subtypes of prion diseases. PrP(C) binds copper and has antioxidation activity. Changes in metal-ion occupancy can lead to significant decline of the antioxidation activity and changes in conformation of the p...
متن کامل[Neuroimaging in the differential diagnosis of prion disease].
MRI including diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) is useful for the diagnosis of prion disease, particularly Creutzfeldt-Jakob disease (CJD). Hyperintensity lesions are predominant on DWI, and are often seen in the cerebral cortex ("cortical ribboning") or both in the cerebral cortex and striatum (anterior dominant). However, clinical and MRI finding...
متن کاملIntensity of human prion disease surveillance predicts observed disease incidence.
BACKGROUND Prospective national screening and surveillance programmes serve a range of public health functions. Objectively determining their adequacy and impact on disease may be problematic for rare disorders. We undertook to assess whether objective measures of disease surveillance intensity could be developed for the rare disorder sporadic Creutzfeldt-Jakob disease (CJD) and whether such me...
متن کاملFamilial Prion Disease Cases Without Mutation in PRNPGene
Phosphorus (P), in the form of phosphate ion (Pi), is a vital element contributing in biomolecule structures, metabolic reactions, signaling pathways and energy transfer within the living cells. The objective of the present study was to assess the influence of fungal infection on Pi metabolism in compare to the effects of phosphate stress in Arabidopsis. Quantification of total P contents showe...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0409651102